"Molecular Biology Tools - The key to new drug targets"
Design of gene expression cassettes with preferential activity in tumor cells: control by viral transcription factors or by promoters from aberrantly expressed genes
Improving strategies for cancer treatment by screening for synergy effects: prodrug converting enzymes as radiation sensitizers and specific antiviral therapeutics
Protein and nucleotide extraction from nerval animal tissues (spinal cord, dorsal root ganglion and other CNS regions): Determining the therapeutic effects of novel drugs in pain and inflammation. Regulation of signal molecules activity in cell system models of colorectal cancer Design and construction of gene expression modifying tools (triple helix-forming oligos (TFOs), siRNA, artificial transcription factors) in order to prevent or intervene with processes of chronic inflammation and autoimmunity. Vector constructions for the generation of molecular biological tools with the objective to therapeutically modify chemokine-chemokine receptor interaction. Heterologic expression of target proteins in procaryontic/ eucaryontic cell systems Molecular diagnosis of chromosomal translocations of the human MLL gene Heterologous expression of Human proteins Homo- and heterologous expression of Dictyostelium proteins Making monoclonal antibodies Differential gene expression and expression profiling Expression of recombinant human therapeutic proteins specific inhibition of gene expression via siRNA re-methylation of tumor suppressor genes in the mamma carcinoma
