Special research
areas 553:
Nitrogen monoxide (NO): generator
and effector systems
Representative: Professor Dr.
Ulrich Förstermann
Pharmacological institute of
the University of Mainz
E-mail: ulrich.forstermann@uni-mainz.de
The special
research area 553 was granted
in 1998 and is an interdisciplinary
research cooperation between
the medicinal departments of
the Johann Wolfgang Goethe University
of Frankfurt and the Johannes
Gutenberg University of Mainz.
Scientists in the research areas
of Biochemistry, Cardiology,
Pharmacology and Physiology
(University of Frankfurt/ ZAFES:
Prof. Dr. Dr. Gerd Geißlinger,
Prof. Dr. Josef M. Pfeilschifter)
and Pharmacology (University
of Mainz) are working in cooperation
in this SFB.
At the center of the investigation
is the small nitrogen monoxide
molecule (NO), which is synthesized
by the NO-synthase (NOS). On
of the research topics is concerned
with the mechanisms responsible
for the NO production in different
cells, tissues and organs. Furthermore,
the wide spread effects of NO
are being investigated. Biochemical,
molecular biological, cell and
organ physiological, morphological
and clinical methods are used
to investigate these research
topics. Fifteen sub-projects
are combined into three project
areas: regulation of the NO
synthase gene expression and
NO dependent gene expression,
regulation of the NO synthase
activities, and regulation of
biological function of NO.
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