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Institute for pharmaceutical technology -
Director Prof. Dr. Jörg Kreuter

 

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Expertise

  • Nanoparticles as drug delivery systems and as carriers for nucleic acids and gens
  • Transpost of drugs across the blood-brain barrier (BBB)
  • Transdermal transport of drugs
  • Stability investigations dosage forms by isothermal heat conduction microcalorimetry

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Resources and Abilities

  • Equipment for the preparation of nanoparticles
  • Photon correlations spectrometer
  • Cryomicrotom
  • Animal facilities for radioactive experimentation
  • Microcalorymeter

 

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Publications

  • Zobel, H. P., Kreuter, J., Werner, D., Noe, C. R., Kümel, G., and Zimmer, A.; Cationic polyhexylcyanoacrylate nanoparticles as carriers for antisense oligo-nucleotides. Antisense Nucl. Acid Drug Devel. 1997, 7: 483 - 493.

  • Reiss, S., von Briesen, H., Rübsamen-Waigmann, H., Kreuter, J., and Langer, K.; Human serum albumin-derived nanoparticles for gene delivery. J. Controlled Rel. 2003, 92: 199 - 208.

  • Löbenberg, R. and Kreuter, J.; Macrophage targeting of azidothymidine: A promising strategy for AIDS therapy. AIDS Res. Human Retrovir. 1996, 12: 1709 - 1715.

  • Bender, A. R., von Briesen, H., Kreuter, J., Duncan, I. B., and Rübsamen-Waigmann, H.; Efficiency of nano-particles as a carrier system for antiviral agents in human immunodificiency virus-infected human monocytes / macrophages in vitro. Antimicrob. Agents Chemother. 1996, 40: 1467 - 1471.

  • Kreuter, J., Alyautdin, R. N., Kharkevich, D. A., and Ivanov, A. A.; Passage of peptides through the blood-brain barrier with colloidal polymer particles (nanoparticles). Brain Res. 1995, 674: 171 - 174.

  • Gulyaev, A. E., Gelperina, S. E., Skidan, I. N., Antropov, A. S., Kivman, G. Ya., and Kreuter, J.; Significant transport of doxorubicin into the brain with polysorbate 80-coated nanoparticles. Pharm. Res. 1999, 16: 1564 – 1569.

  • Friese, A., Seiller, E., Quack, G., Lorenz, B., and Kreuter, J.; Increase of the duration of the anticonvulsive activity of a novel NMDA receptor antagonist using poly(butylcyanoacylate) nanoparticles as a parenteral controlled release system. Eur. J. Pharm. Biopharm. 2000, 49: 103 -109.

  • Kreuter, J., Shamenkov, D., Petrov, V., Ramge, P., Cychutek, K., Koch-Brandt, C., and Alyautdin, R.; Apolipoprotein-mediated transport of nanoparticle-bound drugs across the blood-brain barrier. J. Drug. Target. 2002, 10: 317 - 325.

  • Steiniger, S. C. J., Kreuter, J., Khalansky, A. S., Skidan, I. N., Bobruskin, A. I., Smirnova, Z. S., Severin, S. E., Uhl, R., Kock, M., Geiger, K. D., and Gelperina, S. E.; Chemotherapy of glioblastoma in rats using doxorubicin-loaded nanoparticles. Int. J. Cancer 2004, 109: 759 - 767.

  • Selzer, T., Radau, M., and Kreuter, J.; Use of isothermal heat conduction microcalorimetry to evaluate stability and excipient compatibility of a solid drug. Int. J. Pharm. 1998, 17: 227 - 241.

  • Latsch, S., Selzer, T., Fink, L., and Kreuter, J.; Crystallisation of estradiol containing TDDS determined by isothermal microcalorimetry, X-ray diffraction, and optical microscopy. Eur. J. Pharm. Biopharm. 2003, 56: 43 - 52.

 

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Staff:

  • Dr. Klaus Langer
  • Allessandra Ambruosi
  • Sonja Arnold
  • Alexander Boots
  • Sebastian Dreis
  • Elisabeth Herbert
  • Kerstin Michaelis
  • Heidrun Wartlick

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ZAFES-Coordinator:

 

 

 

INSTITUTES AND
MEDICAL CENTERS

 
 

RHEUMATOLOGY

 
 

GASTROENTEROLOGY - HEPATOLOGY

 
 

PAEDIATRIC HAEMATOL., ONCOL. & HAEMOSTASEOLOGY

 
 

NEURORADIOLOGY

 
 

CLINICAL PHARMACOLOGY

 
 

GENERAL PHARMACOLOGY &
TOXICOLOGY

 
 

IMMUNE PHARMACOLOGY

 
 

INTERDISCIPLINARY PHARMACOLOGY

 

PHARMACEUTICAL TECHNOLOGY

 

PROF. DRESSMAN
PROF. KREUTER

 
 
 

PHARMACEUTICAL CHEMISTRY

 
 

PHARMACEUTICAL
BIOLOGY

 
 

GEORG SPEYER HAUS

 
 

ORGANIC CHEMISTRY &
CHEMICAL BIOLOGY

 
 

NEUROLOGY

 
 

ANESTHESIOLOGY, INTENSIVE CARE AND
PAIN CONTROL

 
 

OBSTETRICS AND GYNECOLOGY

 
 

DEPARTMENT OF DERMATOLOGY & VENEROLOGY

 
 

CARDIOVASCULAR PHYSIOLOGY

 
 

PEDIATRIC PNEUMOLOGY, ALLERGY AND CYSTIC FIBROSIS

MEDICAL VIROLOGY

ECOLOGY, EVOLUTION AND DIVERSITY, DEPARTMENT AQUATIC ECOTOXICOLOGY

 
 

ORAL, CRANIO-
MAXILLOFACIAL AND
FACIAL PLASTIC SURGERY

 
 

GENERAL AND VASCULAR SURGERY

 
 

CLINICAL NEUROANATOMY

 
 

GENERAL PEDIATRICS

 
 

HAEMATOLOGY, ONCOLOGY

 
 

DIAGNOSTIC AND INTERVENTIONAL RADIOLOGY

 
 

BIOCHEMISTRY

 
 

GENERAL PRACTICE

 
 

MPI FOR
BRAIN RESEARCH