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The Institute of Pharmaceutical
Chemistry unites a broad expertise
in identification and characterization
of new drug targets, as well
as in the finding, development
and functional testing of innovative
drugs. For the identification
of drug targets most novel techniques
in Proteomics (mass spectrometry/
electrophoresis) are applied.
Furthermore, methods for signal
transduction research and/ or
systems for assaying gene expression
(e.g. reporter gene assays)
are in use for identification
and characterization of new
target structures.
Development of new drugs is
conducted by state-of -the-art
organic synthesis, guided by
structure-activity-relationships
and pharmacological considerations.
New compounds are subjected
to detailed analytical characterization
(NMR, mass spectrometry etc.).
For the functional analysis
of the compounds different systems
like receptor binding models
and biochemical/ cell biological
methods (e.g. enzyme activity
assays) are established in the
Institute.
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