Institute for pharmaceutical
chemistry -
Prof. Dr. Manfred Schubert-Zsilavecz |
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Expertise
- Medicinal Chemistry
- Synthesis of new PPAR (Peroxisome
proliferator-activated receptor)
ligands
- Drug analysis / Pharmacokinetics
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Resources
and Abilities
- HPLC with UV-, Diode-array-
and Fluorescence detection
- GC
- Routine NMR
- Electroanalytical Methods
(Polarography, Cyclovoltammetry)
- Mass-spectrometry (EI, CI,
FAB)
- Dissolution test systems
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Publications
- S. Schulte-Löbbert,
G. Holoubek, W.E. Müller,
M. Schubert-Zsilavecz, M.
Wurglics Comparison of the
Synaptosomal Uptake Inhibition
of Serotonin by St. John’s
Wort Products“ Journal
of Pharmacy and Pharmacology,
2004, in press
- P. Pfuhl, U. Kärcher,
N. Häring, A. Baumeister,
Mona A. Tawab, M. Schubert-Zsilavecz
Simultaneous Determination
of Niacin, Niacinamide and
Nicotinuric Acid in Human
Plasma J Pharm and Biomed
Anal 2004, in press
- A. Altmann, D. Poeckl, L.
Fischer, M. Schubert-Zsilavecz,
D. Steinhilber, O. Werz Coupling
of boswellic acid-induced
Ca2+ mobilisation and MAPK
activation to lipidmetabolism
and peroxide formation in
human leukocytes Br J Pharmacol
141(2), 2004, 223-32
- J.-H. Keller, M. Karas,
W.E. Müller, D.A. Volmer,
G.P. Eckert, M.A. Tawab, H.
Blume, T. Dingermann, M. Schubert-Zsilavecz
Determination of Hyperforin
in Mouse Brain by Rapid High
Performance Liquid Chromatography/Tandem
Mass Spectrometry Anal Chem
75(22), 2003, 6084-6088
- Mona Abdel Tawab, U. Bahr,
M. Karas, M. Wurglics, M.
Schubert-Zsilavecz Degradation
of Ginsenosides in humans
after Oral Administration
Drug Metabolism and Disposition
31(8), 2003, 1065-1071
- K. Westerhoff, A. Kaunzinger,
M. Wurglics, J. Dressman and
Manfred Schubert-Zsilavecz
Biorelevant Dissolution Testing
of St. John´s Wort Products
Journal of Pharmacy and Pharmacology
54, 2002, 1615-1621
- St. Gebhardt, St. Bihler,
M. Schubert-Zsilavecz, S.
Riva, D. Monti, L. Falcone,
B. Danieli Biocatalytic Generation
of Molecular Diversity: Modification
of Ginsensoside Rb1 by ß-1,4-Galactosyltransferase
and Candida antarctica lipase
Helv. chimica acta 85(7),
2002, 1943-1959
- A. Kaunzinger, A. Baumeister,
D. Cuda, N. Häring, Barbara
Schug, Henning Blume, K. Raddatz,
G. Fischer, M.Schubert-Zsilavecz
Determination of 11-keto-boswellic
acid in human plasma Journal
of Pharmaceutical and Biomedical
Analysis 28 (3-4), 2002, 729-739
- B. Danieli, L. Falcone,
D. Monti, S. Riva, S. Gebhardt,
M. Schubert-Zsilavecz Regioselective
Enzymatic Glycosylation of
Natural Polyhydroxylated Compounds.Galactosylation
and Glucosylation of Protopanaxatriol
Ginsenosides J. Org. Chem.66,
2001, 262-269
- M. Abdel Tawab, U. Bahr,
B. Danieli, S. Gebhardt, M.
Karas, S. Riva, and M. Schubert-Zsilavecz
ESI MSn as a Tool for Rapid
and Sensitive Analysis of
Ginsenosides and their Galactosylderivatives
Helvetica chimica acta 83(4),
2000, 739-747
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Staff:
Work group leader:
- Prof. Dr. M. Schubert-Zsilavecz
(Medicinal Chemistry, Drug
analysis
- Dr. M. Wurglics (Drug analysis,
Pharmacokinetics)
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ZAFES-Coordinator:
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