Department for Neurology -
Prof. Dr. med. U. Ziemann

Expertise

Mechanisms and pharmacological modulation of cortical plasticity in healthy volunteers and in neurological patients in response to central nervous system lesions, especially in stroke patients. Systemphysiological fundamentals of neurorehabilitation.
Clinical neurophysiology in patients with multiple sclerosis. Multimodal evoked potentials as biomarkers and predictors of clinical course. Neurophysiological evaluation of cortical reorganisation and impaired functional connectivity.
Pathophysiology of motorcortex in patients with movement disorders, especially dystonia.

Resources and Abilities

Transcranial magnetic stimulation (single, double stimulation, repetitive magnetic stimulation), Transcranial electrical stimulation
EMG (correlation and coherence analyses)
EEG (motion related potentials, event related desynchronization, coherence analysis)
Stuctural and functional MRI (in collaboration with the Institute for Neuroradiology)
MR-navigated transcranial magnetic stimulation

Publikations

monographies

Boniface S, Ziemann U (2003) Plasticity in the nervous system. Investigations with transcranial magnetic stimulation. Cambridge University Press.

peer-reviewed papers

Kessler KR, Ruge D, Ilic TV, Ziemann U (2005) Short latency afferent inhibition in patients with writer´s cramp. Mov Disord 20(2): 238-42.
Korchounov A, Ilic TV, Schwinge T, Ziemann U (2005) Modification of motor cortical excitability by an acetylcholine-esterase inhibitor. Exp Brain Res 164(3): 399-405.
Ziemann U (2005) Improving disability in stroke with repetitive transcranial magnetic stimulation. Lancet Neurology 4(8): 454-455
Di Lazzaro V, Pilato F, Dileone M, Tonali PA, Ziemann U (2005) Dissociated Effects of Diazepam and Lorazepam on Short Latency Afferent Inhibition. J Physiol 569(1): 315-323
Jung P, Ziemann U (2005) Transcranial magnetic stimulation in multiple sclerosis. Klin Neurophysiol 36: 155-160
Ziemann U, Ilic TV, Pauli C, Meintzschel F, Ruge D (2004) Learning modifies subsequent induction of LTP-like and LTD-like plasticity in human motor cortex. J Neurosci 24(7): 1666-1672.
Ilic TV, Korchounov A, Ziemann U (2003) Methylphenydate facilitates and disinhibits the motor cortex in intact humans. NeuroReport 14: 773-776.
Korchounov A, Ilic TV, Ziemann U (2003) The alpha2-adrenergic agonist guanfacine reduces excitability of human motor cortex through disfacilitation and increase of inhibition. CLINPH 114(10): 1834-1840.
Ziemann U, Wittenberg GF, Cohen LG (2002) Stimulation-induced within-representation and across-representation plasticity in human motor cortex. J Neurosci 22 (13): 5563-5571.
Ilic TV, Meintzschel F, Cleff U, Ruge D, Kessler KR, Ziemann U (2002) Short-interval paired-pulse inhibition and facilitation of human motor cortex: The dimension of stimulus intensity. J Physiol 545.1: 153-167
Ilic TV, Korchounov A, Ziemann U (2002) Complex modulation of human motor cortex excitability by the specific serotonin re-uptake inhibitor sertraline. Neuroscience Letters 319: 116-120.
Muellbacher W, Ziemann U, Wissel J, Dang N, Kofler M, Facchini S, Boroojerdi B, Poewe W, Hallett M (2002) Early consolidation in human primary motor cortex. Nature 415: 640-644.
Ziemann U, Muellbacher W, Hallett M & Cohen LG (2001) Modulation of practice-dependent plasticity in human cortex. Brain 124: 1171-1181.
Waldvogel D, Van Gelderen P, Muellbacher W, Ziemann U, Immisch I, Hallett M (2000) The relative metabolic demand of inhibition and excitation. Nature 406: 995-998.