Department for Neurology -
PD Dr. med. T. Neumann-Haefelin

Expertise

stroke model (advanced MR-techniques, spectroscopic visualizations, stroke scales)
animal model of cerebral ischemia (dynamics of DWI lesions, thrombolysis-induced disorders of the blood brain barrier)

Resources and Abilities

magnet resonance tomography and spectroscopy (1.5 and 3 T in cooperation with the Institute for Neuroradology)
focal cerebral ischemia in rats and mice (filament model, clot model)
Histology / Immune histochemistry
endothelial cell cultures (in cooperation with the Cardiovascular Physiology)

Publikations

T. Neumann-Haefelin, R. du Mesnil de Rochemont, et al. (2004). "Effect of incomplete (spontaneous and postthrombolytic) recanalization after middle cerebral artery occlusion: a magnetic resonance imaging study." Stroke 2004, 35(1): 109-14.
Stengel, T. Neumann-Haefelin, O.C. Singer, C. Neumann-Haefelin, F.E. Zanella, H. Lanfermann, U. Pilatus. Multiple Spin-Echo Spectroscopic Imaging for Rapid Quantitative Assessment of N-Acetylaspartate and Lactate in Acute Stroke. Magn. Reson. Med., 2005.
Singer OC, Du Mesnil De Rochemont R, Foerch C, Stengel A, Sitzer M, Lanfermann H, Neumann-Haefelin T. Early functional recovery and the fate of the diffusion/perfusion mismatch in patients with proximal middle artery occlusion. Cerebrovasc Dis. 2004; 17: 13-20
Singer OC, de Rochemont Rdu M, Foerch C, Stengel A, Lanfermann H, Sitzer M, Neumann-Haefelin T. Relation between relative cerebral blood flow, relative cerebral blood volume, and mean transit time in patients with acute ischemic stroke determined by perfusion-weighted MRI. J Cereb Blood Flow Metab. 2003; 23:605-11
Stengel, T. Neumann-Haefelin, H. Lanfermann, O.C. Singer, C. Neumann-Haefelin, F. Zanella, U. Pilatus. Mismatch between Lactate and ADC Changes in Acute Stroke. MAGMA, Vol. 16, p. 167-168 , 2003.
Neumann-Haefelin T, Kastrup A, de Crespigny A, Yenari MA, Ringer T, Sun GH, Moseley ME. Serial MRI after transient focal cerebral ischemia in rats: dynamics of tissue injury, blood-brain barrier damage, and edema formation. Stroke. 2000;31:1965-73.
Neumann-Haefelin T, Moseley ME, Albers GW. New magnetic resonance imaging methods for cerebrovascular disease: emerging clinical applications. Ann Neurol. 2000;47:559-70.
Neumann-Haefelin T, Wittsack HJ, Wenserski F, Siebler M, Seitz RJ, Modder U, Freund HJ. Diffusion- and perfusion-weighted MRI. The DWI/PWI mismatch region in acute stroke. Stroke. 1999;30:1591-7.