Medical Clinic I:
Gastroenterology / Nutritional- and Prevention Medicine
Prof. Dr. med. Dr. oec. troph. Jürgen Stein

 

>

Expertise

  • Development of new immunomodulatory strategies in inflammatory bowel disease
  • Secondary prevention of colorectal cancer
  • Anticarcinogenic effects of secondary plant extracts (prebiotics, polyphenols)

>

Resources and Abilities

  • 2D-Gel electrophoresis
    semi-quantitative PCR (Pico-Green), DNA-sequencing, cloning, transfection/transformation
  • Immunohistochemistry
  • HPLC
  • Radioisotope analyser
  • Infra red absorption spectroscopy
  • Exhaled hydrogen monitoring
    - H2-breath tests, C14-breath tests
  • FACS
  • Patchclamp-Studies, Calcium-Imaging (single cells and organotypic slices)
  • Experimental animal models:
    - colitis-models (TNBS, DSS, IL-2)
    - cystic fibrosis-model (CFTR-knockout mice)

 

>

Publications

  • Bott C, Rudolph MW, Schirrmacher S, Skalsky B, Petereit H-U, Langguth P, Dressman JB, Stein J. In vivo evaluation of a novel pH- and time-based multi-unit drug deilivery system. Aliment Pharmacol Ther (submitted).

  • Schröder O, Blumenstein I, Schulte-Bockholt A, Stein J. Combining infliximab and methotrexate in fistulising Crohn's disease resistant or intolerant to azathioprine. Aliment Pharmacol Ther 2004 Feb; 19(3): 295-301.

  • Schröder O, Stein J. Low dose methotrexate in inflammatory bowel disease: current status and future directions. Am J Gastroenterol 2003 Mar; 98(3): 530-7.

  • Jordan A, Stein J. Effect of an omega-3 fatty acid containing lipid emulsion alone and in combination with 5-fluorouracil (5-FU) on growth of the colon cancer cell line Caco-2. Eur J Nutr. 2003 Dec; 42(6): 324-31.

  • Wolter F, Turchanowa L, Stein J. Resveratrol-induced modification of polyamine metabolism is accompanied by induction of c-Fos. Carcinogenesis. 2003 Mar; 24(3): 469-74.

  • Trojan J, Povse N, Schröder O, Stein J. A new immunological test strip device for the rapid, qualitative detection of faecal occult blood. Z Gastroenterol 2002 Nov; 40(11): 921-4.

  • Gaschott T, Steinmeyer A, Steinhilber D, Stein J. ZK 156718, a low calcemic, antiproliferative, and prodifferentiating vitamin D analog. Biochem Biophys Res Commun. 2002 Jan 11; 290(1): 504-9.

  • Wächtershauser A, Akoglu B, Stein J. HMG-CoA reductase inhibitor mevastatin enhances the growth inhibitory effect of butyrate in the colorectal carcinoma cell line Caco-2. Carcinogenesis. 2001 Jul; 22(7): 1061-7.

  • Gaschott T, Wächtershauser A, Steinhilber D, Stein J. 1,25-Dihydroxycholecalciferol enhances butyrate-induced p21(Waf1/Cip1) expression. Biochem Biophys Res Commun. 2001 Apr 27; 283(1): 80-5.

 

>

Staff:

  • Dr. med. Oliver Schröder

>

ZAFES-Coordinator:

 

 

 

 

INSTITUTES AND
MEDICAL CENTERS

 
 

RHEUMATOLOGY

 

GASTROENTEROLOGY - HEPATOLOGY

 

PROF. ZEUZEM
PROF. STEIN
PD DR. TEUBER

 
 
 

PAEDIATRIC HAEMATOL., ONCOL. & HAEMOSTASEOLOGY

 
 

NEURORADIOLOGY

 
 

CLINICAL PHARMACOLOGY

 
 

GENERAL PHARMACOLOGY &
TOXICOLOGY

 
 

IMMUNE PHARMACOLOGY

 
 

INTERDISCIPLINARY PHARMACOLOGY

 
 

PHARMACEUTICAL TECHNOLOGY

 
 

PHARMACEUTICAL CHEMISTRY

 
 

PHARMACEUTICAL
BIOLOGY

 
 

GEORG SPEYER HAUS

 
 

ORGANIC CHEMISTRY &
CHEMICAL BIOLOGY

 
 

NEUROLOGY

 
 

ANESTHESIOLOGY, INTENSIVE CARE AND
PAIN CONTROL

 
 

OBSTETRICS AND GYNECOLOGY

 
 

DEPARTMENT OF DERMATOLOGY & VENEROLOGY

 
 

CARDIOVASCULAR PHYSIOLOGY

 
 

PEDIATRIC PNEUMOLOGY, ALLERGY AND CYSTIC FIBROSIS

MEDICAL VIROLOGY

ECOLOGY, EVOLUTION AND DIVERSITY, DEPARTMENT AQUATIC ECOTOXICOLOGY

 
 

ORAL, CRANIO-
MAXILLOFACIAL AND
FACIAL PLASTIC SURGERY

 
 

GENERAL AND VASCULAR SURGERY

 
 

CLINICAL NEUROANATOMY

 
 

GENERAL PEDIATRICS

 
 

HAEMATOLOGY, ONCOLOGY

 
 

DIAGNOSTIC AND INTERVENTIONAL RADIOLOGY

 
 

BIOCHEMISTRY

 
 

GENERAL PRACTICE

 
 

MPI FOR
BRAIN RESEARCH