Institute for Pharmaceutical Technology -
Prof. Dr. Jennifer Dressman

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Expertise

• Predicting the oral absorption of drugs
  
• Improving oral drug absorption through formulation
  
• Improving therapy of diseases of the gastrointestinal tract
  
  

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Resources and Abilities

• Production of solid dosage forms, including pellet, tablet and coating technologies
  
• Dissolution testing, including development of biorelevant tests (with a view to in vitro-in vivo correlation)
  
• Analytical capabilities for in vitro and biological samples
  
• Software for establishing in vitro-in vivo correlations
  
  

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Staff:

• Dr. Sandra Klein
  
  

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Publications

• Vogt M, Vertzoni M, Kunath K, Reppas C, Dressman J: Cogrinding enhances the oral bioavailability of EMD 57033, a poorly water soluble drug, in dogs. EJPB 2008; 68: 338-345.
  
• Swidan S, Reppas C, Tobey S, Turowski M, Dressman JB: Hydroxypropylmethylellulose (HPMC) reduces cholesterol in mildly hypercholerestemic individuals. Eur J Clin Nutr 2007; Epub ahead of print.
  
• Kalantzi L, Goumas K, Kalioras V, Abrahamsson B, Dressman JB, Reppas C: Characterization of the human upper gastrointestinal contents under conditions simulating bioavailability/bioequivalence studies. Pharm Res 2006; 23: 165-176.
  
• Fürst T, Bott C, Stein J, Dressman JB: Enteric coated Cholylsarcosine granules for the treatment of short bowel syndrome. J Pharm Pharmacology 2005;) 57: 53-60.
  
• Willmann S, Schmitt W, Keldernich J, Dressman JB: A Physiological Model for the Estimation of the Fraction Dose Absorbed in Humans. J Med Chem 2004; 47: 4022-4031.