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The Institute of Pharmaceutical Chemistry unites a broad expertise in identification and characterization of new drug targets, as well as in the finding, development and functional testing of innovative drugs. For the identification of drug targets most novel techniques in Proteomics (mass spectrometry/ electrophoresis) are applied. Furthermore, methods for signal transduction research and/ or systems for assaying gene expression (e.g. reporter gene assays) are in use for identification and characterization of new target structures.
Development of new drugs is conducted by state-of -the-art organic synthesis, guided by structure-activity-relationships and pharmacological considerations. New compounds are subjected to detailed analytical characterization (NMR, mass spectrometry etc.). For the functional analysis of the compounds different systems like receptor binding models and biochemical/ cell biological methods (e.g. enzyme activity assays) are established in the Institute.
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