Institute for Organic Chemistry and Chemical Biology -
Prof. Dr. Michael Göbel

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Expertise

• The group is interested in the synthesis of catalytically active receptor molecules able to transform substrates within host-guest complexes. Stereoselective C-C bond forming reactions are studied as well as the sequence specific cleavage of nucleic acids. Molecular recognition of biopolymers, especially of RNA and template controlled oligomerization of RNA are further research projects.
  
  

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Resources and Abilities

• Synthesis of functional molecules
  
• Molecular recognition and catalysis by anion receptors
  
• Small molecule ligands for RNA
  
• Synthetic ribonucleases
  
• DNA cleaving artificial phosphodiesterases
  
• Template controlled oligomerization of RNA
  
  

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Staff:

• Dr. Ute Scheffer
  
  

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Publications

• Akalay D, Duerner G, Goebel MW: A first case of asymmetric catalysis induced by metal-free bisoxazolines. Eur J Org Chem 2008;: 2365-2368.
  
• Schueller A, Suhartono M, Fechner U, Tanrikulu Y, Breitung S, Scheffer U, Goebel MW, Schneider G: The concept of template-based de novo design from drug-derived molecular fragments and its application to TAR RNA. J Comput-Aided Mol Des 2008; 22:59-68.
  
• Suhartono M, Weidlich M, Stein T, Karas M, Duerner G, Goebel MW: Synthesis of non-natural aromatic alpha -amino acids by a Heck reaction. Eur J Org Chem 2008;: 1608-1614.
  
• Akalay D, Duerner G, Bats JW, Bolte M, Goebel MW: Synthesis of C2-symmetric bisamidines: A new type of chiral metal-free Lewis Acid Analogue interacting with carbonyl groups. J Org Chem 2007; 72:5618-5624.
  
• Givehchi A, Ludwig V, Boden O, Krebs A, Scheffer U, Goebel M, Schneider G: Classification and prediction of tripeptides inhibiting HIV-1 Tat/TAR-RNA interaction using a self-organizing map. Lett Drug Des Discovery 2007; 4:410-416.
  
• Nandi CK, Parui PP, Brutschy B, Scheffer U, Goebel M: Fluorescence correlation spectroscopy at single molecule level on the Tat-TAR complex and its inhibitors. Biopolymers 2007; 89:17-25.
  
• Ludwig V, Krebs A, Stoll M, Dietrich U, Ferner J, Schwalbe H, Scheffer U, Durner G, Gobel MW: Tripeptides from synthetic amino acids block the Tat-TAR association and slow down HIV spread in cell cultures. Chembiochem 2007; 8:1850-1856.
  
• Morgner N, Barth HD, Schmidt TL, Heckel A, Scheffer U, Göbel M, Fucini P, Brutschy B: Detecting Specific Ligand Binding to Nucleic Acids: A Test for Ultrasoft Laser Mass Spectrometry. Z Phys Chem 2007; 221:689-704.
  
• Tanrikulu Y, Nietert M, Scheffer U, Proschak E, Grabowski K, Schneider P, Weidlich M, Karas M, Goebel M, Schneider G: Scaffold hopping by fuzzy pharmacophores and its application to RNA targets. ChemBioChem 2007; 8:1932-1936.
  
• Gnaccarini C, Peter S, Scheffer U, Vonhoff S, Klussmann S, Göbel MW: Site Specific Cleavage of RNA by a Metal Free Artificial Nuclease Attached to Antisense Oligonucleotides. J Am Chem Soc 2006; 128:8063-8067.
  
• Renner S, Ludwig V, Boden O, Scheffer U, Göbel MW, Schneider G: New inhibitors of the Tat-TAR RNA interaction found with a fuzzy pharmacophore model. ChemBioChem 2005; 6:1119-1125.
  
• Riguet E, Désiré J, Boden O, Ludwig V, Göbel M, Bailly C, Décout J-L: Neamine dimers targeting the HIV-1 TAR RNA. Bioorg Med Chem Lett 2005; 15:4651-4655.
  
• Scheffer U, Strick A, Ludwig V, Peter S, Kalden E, Göbel MW: Metal-Free Catalysts for the Hydrolysis of RNA Derived from Guanidines, 2- Aminopyridines, and 2 Aminobenzimidazoles. J Am Chem Soc 2005; 127:2211-2217.
  
• Scheffer U, Göbel M: Fluorescence-Based On-Line Detection as an Analytical Tool in RNA Electrophoresis. In Oligonucleotide Synthesis: Methods and Applications.P. Herdewijn, ed., 2004;: 261-272.
  
• Hey M, Hartel C, Göbel MW: Nonenzymatic Oligomerization of Ribonucleotides: Towards in vitro Selection Experiments. Helv Chim Acta 2003; 86:844-854.
  
• Krebs A, Ludwig V, Boden O, Göbel MW: Targeting the HIV Trans-Activation Responsive Region–Approaches Towards RNA-Binding Drugs. ChemBioChem 2003; 4:972-978.
  
• Pitsch S, Scheffer U, Hey M, Strick A, Göbel MW: On Facts and Artefacts: The Difficulty to Evaluate an Artificial Nuclease. Helv Chim Acta 2003; 86:3740-3752.
  
• Tsogoeva SB, Dürner G, Bolte M, Göbel MW: C2-Chiral Bis(Amidinium)-Catalyst for a Diels-Alder Reaction Constituting the Key Step of the Quinkert-Dane Estrone Synthesis. Eur J Org Chem 2003;: 1661-1664.