Institute of Neuroradiology -
Prof. Dr. Friedhelm Zanella

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Expertise

• Optimization of brain tumor diagnostic in regard to the tumor entity and malignancy
• Quantification of diffuse and focal changes in the metabolism of brain tissue
• Detection of biochemical markers (metabolites) to evaluate the potential effects of pharmacological therapies
• Quantification of the cerebral blood flow in patients who have a cerebrovascular disease
• Evaluation of drug mediated changes in cerebral metabolism and in cerebral blood flow
• Visualization of neurofunctional areas and variations in these regions after pharmacological treatment
• Detection of early metabolic changes in Alzheimer disease and pharmaceutical influence of these changes
  
  
  

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Resources and Abilities

• 3 Tesla Magnetic Resonance Tomography including
  - Proton MR Spectroscopy
  - Diffusion-weighted Imaging
  - Spin labeling methods and MR Angiographie
  - Functional MR Imaging and Brain voyager® software
• BRUKER BRX 400 Spectrometer
• Histological laboratory, molecular biology work area, DNA-analysis
  
  
  

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Staff:

• Dr. rer nat. Pilatus (Protonen-MR-Spektroskopie)
• Dr. rer. nat. Preibisch ( funktionelle Bildgebung, spin labeling Verfahren)
• PD Dr. med Nafe (Neuropathologie, zelluläre Morphometrie, Histomorphologie, Molekularbiologie)
• PD Dr. med H. Lanfermann (klinische Studien)
  
  

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Publications

• Preibisch C, Haase A. Perfusion imaging using spin-labeling methods: Contrast to noise comparison in functional MRI applications. Magn Reson Med 46: 172-182, 2001.
  
  
• Herminghaus S, Frolich L, Gorriz C, Pilatus U, Dierks T, Wittsack HJ, Lanfermann H, Maurer K, Zanella FE. Brain metabolism in Alzheimer disease and vascular dementia assessed by in vivo proton magnetic resonance spectroscopy. Psychiatry Res. 2003 Jul 30;123(3):183-90.
  
  
• Herminghaus S, Pilatus U, Moller-Hartmann W, Raab P, Lanfermann H, Schlote W, Zanella FE. Increased choline levels coincide with enhanced proliferative activity of human neuroepithelial brain tumors. NMR Biomed. 2002 Oct;15(6):385-92.
  
  
• Nafe R, Herminghaus S, Raab P, Wagner S, Pilatus U, Schneider B, Schlote W, Zanella F, Lanfermann H. Preoperative proton-MR spectroscopy of gliomas--correlation with quantitative nuclear morphology in surgical specimen. J Neurooncol. 2003 Jul;63(3):233-45.
  
  
• Preibisch C, Pilatus U, Bunke J, Hoogenraad F, Zanella F, Lanfermann H. Functional MRI using sensitivity-encoded echo planar imaging (SENSE-EPI). Neuroimage. 2003 Jun;19(2 Pt 1):412-21.
  
  
• Preibisch C, Neumann K, Raab P, Euler HA, von Gudenberg AW, Lanfermann H, Giraud AL. Evidence for compensation for stuttering by the right frontal operculum. Neuroimage. 2003 Oct;20(2):1356-64.
  
  
• Preibisch C, Raab P, Neumann K, Euler HA, von Gudenberg AW, Gall V, Lanfermann H, Zanella F. Event-related fMRI for the suppression of speech-associated artifacts in stuttering. Neuroimage. 2003 Jul;19(3):1076-84.
  
  
• Preibisch C, Berg D, Hofmann E, Solymosi L, Naumann M. Cerebral activation patterns in patients with writer's cramp: a functional magnetic resonance imaging study. J Neurol. 2001 Jan;248(1):10-7
  
  
• Nafe R, Herminghaus S, Raab P, Wagner S, Pilatus U, Schlote W, Zanella F, Lanfermann H. Correlation between preoperative magnetic resonance spectroscopic data on high grade gliomas and morphology of Ki-67-positive tumor cell nuclei. Anal Quant Cytol Histol. 2003 Jun;25(3):131-8.
  
  
• Nafe R, Schlote W. Topometric analysis of diffuse astrocytomas. Anal Quant Cytol Histol. 2003 Feb;25(1):12-8.
  
  
• Pilatus U, Aboagye E, Artemov D, Mori N, Ackerstaff E, Bhujwalla ZM. Real-time measurements of cellular oxygen consumption, pH, and energy metabolism using nuclear magnetic resonance spectroscopy. Magn Reson Med. 2001 May;45(5):749-55.