Physiology I: Cardiovascular Physiology -
Prof. Dr. Ralf Brandes

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Expertise

• Mechanisms of vascular redox regulation
  
• Lipid signaling in the vasculature
  
• Vascular autoacoid release and actions
  
• Pathomechanisms in vascular disease development
  
• Integrative physiology
  
  

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Resources and Abilities

• Integrative physiology in mice (models of atherosclerosis, hypertension, stroke and progressive renal failure, telemetry, hypoxia)
  
• Analysis of vascular and cellular reactive oxygen species (ROS) formation and their biological effects
  
• Cell culture models of monolayer permeability, cell migration, angiogenesis
  
• Culture of primary cells from vessels and brain
  
  

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Publications

• Heumüller S, Wind S, Barbosa-Sicard E, Schmidt HH, Busse R, Schröder K, Brandes RP: Apocynin is not an inhibitor of vascular NADPH oxidases but an antioxidant. Hypertension 2008; 51:211-217.
  
• Schröder K, Helmcke I, Palfi K, Krause K.-H., Busse R, Brandes RP: Nox1 mediates basic fibroblast growth factor-induced migration of vascular smooth muscle cells Arterioscler Thromb Vasc Biol 2007; 27:1736-1743.
  
• Kahles T, Luedike P, Endres M, Galla H-J, Steinmetz H, Busse R, Neumann-Haefelin T, Brandes RP: NADPH oxidase plays a central role for blood-brain barrier damage in experimental stroke, Stroke 2007; 38:3000-3007.
  
• Büssemaker E, Pistrosch F, Forster S, Herbrig K, Gross P, Passauer J, Brandes RP: Rho-kinase contributes to basal vascular tone in man – role of endothelium-derived nitric oxide. Am J Physiol Heart Circ Physiol 2007; 293:H541-547.
  
• Jung O, Marklund SL, Xia N, Busse R, Brandes RP: inactivation of extracellular superoxide dismutase contributes to the development of high-volume hypertension. Arterioscler Thromb Vasc Biol 2007; 27:470-477.
  
• Schröder K, Vecchione C, Jung O, Schreiber JG, Schiri-Sverdlov R, van Gorp P, Busse R, Brandes RP: The xanthine oxidase inhibitor tungsten prevents the development of atherosclerosis in ApoE knockout mice fed a Western-type diet. Free Radical Bio Med 2006; 141:1353-1360.
  
• Ambasta RK, Schreiber JG, Janiszewski M, Busse R, Brandes RP: Noxa1 is a central component of the smooth muscle NADPH oxidase in mice, Free Radical Biol Med 2006; 41:193-201.
  
• Jung O*, Brandes RP*, Kim IH, Schweda F, Schmidt R, Hammock BD, Busse R, Fleming I. The soluble epoxide hydrolase is a main effector of angiotensin II-induced hypertension, Hypertension 2005; 45:1-7. *both authors contributed equally to this work
  
• Ambasta RK, Kumar P, Griendling KK, Schmidt HHHW, Busse R, Brandes RP, Direct interaction of the novel Nox proteins with p22phox is required for the formation of a functionally active NADPH oxidase, J Biol Chem 2004; 479:45935-45941.
  
• Jung O, Schreiber JG, Geiger H, Pedrazzini T, Busse R, Brandes RP. The gp91phox-containing NADPH oxidase mediates endothelial dysfunction in renovascular hypertension. Circulation 2004; 109:1795-1801.
  
• Jung O, Marklund SL, Geiger H, Pedrazzini T, Busse R, Brandes RP. Extracellular superoxide dismutase is a major determinant of nitric oxide bioavailability. In vivo and ex vivo evidence from ecSOD-deficient mice. Circ Res. 2003; 93:622-629.
  
• Brandes RP, Beer S, Ha T, Busse R. Withdrawal of cerivastatin induces monocyte chemoattractant protein 1 and tissue factor expression in cultured vascular smooth muscle cells. Arterioscler Thromb Vasc Biol. 2003; 23:1794-1800.
  
• Büssemaker E, Popp R, Fisslthaler B, Larson CM, Fleming I, Busse R, Brandes RP. Aged spontaneously hypertensive rats exhibit a selective loss of EDHF-mediated relaxation in the renal artery. Hypertension 2003; 42:562-568.
  
• Büssemaker E, Popp R, Fisslthaler B, Larson CM, Fleming I, Busse R, Brandes RP. Hyperthyroidism enhances endothelium-dependent relaxation in the rat renal artery. Cardiovasc. Res. 2003; 59:181-188.
  
• Vecchione C, Brandes RP. Withdrawal of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors elicits oxidative stress and induces endothelial dysfunction in mice. Circ Res 2002; 91:173-179.