Clinic III: Pediatric Hematology, Oncology, and Hemostaseology -
PD Dr. Thomas Lehrnbecher |
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Expertise
- The group mainly works
in the field of infectious
complications in immunocompromised
patients. A focus is on the
characterisation of low- and
high risk groups using clinical
parameters and genetic polymorphisms
of the immune system. In addition,
invasive fungal infections
are investigated. Current
activities include the detection,
characterization, and expansion
of aspergillus-specific T
cells with the goal of adoptive
immunotherapy. The group is
also involved in multi-center
studies on the early detection
of invasive fungal disease
in children with AML and on
the reconstitution of the
immune system of children
and the effects of re-vaccination
after chemotherapy.
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Resources
and Abilities
- DNA sequencing
- PCR, RT-PCR
- Detection and enrichment
of IFNg secreting cells by
cytokine secretion assay
- Selection and cloning of
CMV and aspergillus specific
T cells
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Publications
- Beck O, Topp MS, Koehl U,
Roilides E, Simitsopoulou
M, Hanisch M, Sarfati J, Latgé
JP, Klingebiel T, Einsele
H, Lehrnbecher T. Generation
of highly purified and functionally
active human TH1-cells against
Aspergillus fumigatus. Blood
2006 (in press)
- Lehrnbecher T, Bernig T,
Hanisch M, Koehl U, Behl M,
Reinhardt D, Creutzig U, Klingebiel
T, Chanock SJ, Schwabe D Common
genetic variants in the interleukin-6
and chitotriosidase genes
are associated with the risk
for severe infection in children
undergoing therapy for acute
myeloid leukemia. Leukemia
2005; 19: 1745-1750
- Creutzig, U, Zimmermann
M, Reinhardt D, Dworzak M,
Stary J, Lehrnbecher T Early
deaths and treatment-related
mortality in children undergoing
therapy for acute myeloid
leukemia: Analysis of the
multicenterclinical trials
AML-BFM 93 and AML-BFM 98.
J Clin Oncol 2004; 21: 4384-4393
- Lehrnbecher T, Fleischhack
G, Hanisch M, Deinlein F,
Simon A, Bernig T, Chanock
SJ, Klingebiel T. Circulating
levels and promoter polymorphisms
of IL-6 and IL-8 in pediatric
cancer patients with fever
and neutropenia. Haematologica
2004; 89:234-236
- Lehrnbecher T, Varwig D,
Kaiser J, Reinhardt D, Klingebiel
T, Creutzig U. Infectious
complications in pediatric
acute myeloid leukemia: analysis
of the prospective multi-institutional
clinical trial AML-BFM 93.
Leukemia 2004; 18: 72-77
- Lehrnbecher T, Foster CB,
Zhu S, Venzon D, Steinberg
SM, Wyvill K, Metcalf, JA,
Cohen SS, Kovacs J, Yarchoan
R, Blauvelt A, Chanock SJ.
Variant genotypes of FcgRIIIa
influence the development
of Kaposi´s sarcoma
in HIV-infected men. Blood
2000; 95: 2386-2390
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