Pedatric Pneumology, Allergology and Mucoviscidosis -
Prof. Dr. Stefan Zielen

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Expertise

• The Division of Pediatric Pneumology, Allergy and Cystic Fibrosis is involved in the management of children and adolescents with acute and chronic lung diseases. A team of specialized physicians and nurses takes care of children and their families. We provide all modern tools for diagnosis (e.g., lung function measurement in infants and children, bronchial provocation tests, measurement of exhaled NO, bronchoscopy, gastroscopy) and treatment (e.g., tailored inhalation regimens, specific immunotherapies). Our certified laboratory with specialized technicians offers a broad spectrum of immunological and allergological testing.
  
• Clinical and laboratory research activities focus on the analysis of molecular and cellular events involved in the pathogenesis of chronic lung disease (e.g., asthma, allergy, cystic fibrosis, ataxia telangiectasia). Besides established and evidence-based clinical and laboratory techniques, we further deal with new diagnostic and therapeutic approaches in order to gain deeper insights into the complex mechanisms of inflammatory processes to develop new therapeutic approaches. In this regard, our major topic is to test new compounds (e.g., unsaturated fatty acids, probiotics, autovaccine) in prevention of atopic diseases.
  
  

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Resources and Abilities

• Outpatient and inpatient clinical diagnosis and therapy of bronchopulmonary diseases
  
• Specialized ambulatory care unit for all patients with allergic and respiratory disease
  
• Detection of exhaled NO, CO, H2O2
  
• Phase I-III trials to gain deeper insights into diagnosis, therapies and prevention of respiratory diseases.
  
• Characterization of bronchial inflammation in cystic fibrosis
  
• Bronchial inflammation after exposure to tobacco smoke
  
• Laboratory facility for diagnosis of allergies and immune competence
  
• Research laboratory for cell culture (cell isolation and stimulation)
  
• FACS (cell cycle, apoptosis, oxidative stress, mitochondrial membrane potential)
  
• Animal model (Atm-/- mouse)
  
  

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Staff

• Dr. Markus Rose (Infection and immunization)
  
• Dr. Johannes Schulze (Allergen,- and LPS-provocation model)
  
• Dr. Martin Rosewich (Bronchial inflammation in smokers)
  
• Dr. Olaf Eickmeier (Cystic fibrosis)
  
• Dr. Martin Christmann (Ataxia telangiectasia)
  
• Dr. Ralf Schubert (Labor)

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Publications

• Schubert R, Kitz R, Beermann C, Rose MA, Lieb A, Sommerer PC, Moskovits J, Alberternst H, Böhles HJ, Schulze J, and S. Zielen. Effect of n-3 Polyunsaturated Fatty Acids in Asthma after low dose Allergen Challenge. International Archives of Allergy and Immunology (2008) accepted for publication.
  
• Schubert R, Kitz R, Beermann C, Rose MA, Baer PC, Zielen S, Boehles H. Influence of low-dose polyunsaturated fatty acids supplementation on the inflammatory response of healthy adults. Nutrition (2007) 23: 724-730.
  
• Schulze J, Rose M, Zielen S. Beekeepers anaphylaxis: successful immunotherapy covered by omalizumab. Allergy (2007) 62: 963-964.
  
• Kitz R, Rose MA, Borgmann A, Schubert R, Zielen S. Systemic and bronchial inflammation following LPS inhalation in asthmatic and healthy subjects. J Endotoxin Res (2006)m12: 367-374.
  
• Erker L, Schubert R, Elchuri S, Huang TT, Tarin D, Mueller K, Zielen S, Epstein CJ, Wynshaw-Boris A. Effect of the reduction of superoxide dismutase 1 and 2 or treatment with alpha-tocopherol on tumorigenesis in Atm-deficient mice. Free Radic Biol Med (2006) 41: 590-600.
  
• Schmitt-Grohe S, Naujoks C, Bargon J, Wagner TO, Schubert R, Hippe V, Zielen S. Interleukin-8 in whole blood and clinical status in cystic fibrosis. Cytokine (2005) 29:18-23.
  
• Bisgaard H, Zielen S, Garcia-Garcia L, Johnston SL, Gilles L, Menten J, Tozzi CA, Polos P. Montelukast Reduces Asthma Exacerbations in 2 to 5 year old Children with Intermittent Asthma. Am J Respir Crit Care Med (2004) 171: 315-322.
  
• Bez C, Schubert R, Kopp M, Ersfeld Y, W, Berg AV, Wahn U, Zielen S. Effect of anti-immunoglobulin E on nasal inflammation in patients with seasonal allergic rhinoconjunctivitis. Clin Exp Allergy (2004) 34: 1079-1085.
  
• Rose M, Hey C, Kujumdshiev S, Gall V, Schubert R, Zielen S. Immunogenicity of pneumococcal vaccination of patients with cochlear implants. J Infect Dis (2004) 190: 551-557.
  
• Schubert R, Erker L, Barlow C, Yakushiji H, Larson D, Russo A, Mitchell JB, Wynshaw-Boris A.Cancer chemoprevention by the antioxidant tempol in Atm-deficient mice. Hum Mol Genet. (2004) 13: 1793-1802.