Medical Virology -
Prof. Dr. Hans Wilhelm Doerr

>

Expertise

• Development of chemically defined cell culture media
  
• Investigation of intracellular signaling pathways induced by CMV in different cell cultures
  
• Genotype database of HIV-1, HBV, HCV, HPV, VZV
  
• Cellular resistance factors in HIV infection
  
• Cell culture-based propagation of SARS-CoV and influenza viruses
  
• Development of antivirals (in vitro)
  
• Setup of a paediatric-tumour based cell culture storage
  
• Development of new tumour therapy regimens
  
• Development of a cell culture model for in vitro research of WNV retinitis
  
• Measurement of NK-cell activity and cytotoxic lymphocytes
  
• Use of HCV-Pseudotypes for stimulation of T-lymphocytes and measurement of neutralising antibodies
  
  

>

Resources and Abilities

• Laboratory diagnostics and collection of viral and chlamydial strains from patients
  
• Cell culture collection and technologies
  
• Molecular biology (PCR, viral NA sequencing)
  
• Electron microscopy
  
  

>

Publications

• Schmidt-Chanasit J, Bleymehl K, Schad SG, Gross G, Ulrich RG, Doerr HW: Novel varicella-zoster virus glycoprotein E gene mutations associated with genotypes A and D. J Clin Microbiol 2008; 46:325-327.
  
• Schmidt-Chanasit J, Meisel H, Hofmann J, Rang A, Lambrecht E, Ulrich RG, Doerr HW: Clinical course and laboratory parameters of the first Dobrava-Belgrade hantavirus infection imported to Germany. J Clin Virol 2008; 42:91-93.
  
• Schmidt-Chanasit J, Bleymehl K, Rabenau HF, Ulrich RG, Cinatl J, Jr., Doerr HW: In vitro replication of varicella-zoster virus in human retinal pigment epithelial cells. J Clin Microbiol 2008; 46:2122-2124.
  
• Berger A, Rabenau H, Allwinn R, Doerr HW: Evaluation of the new ARCHITECT anti-HCV screening test under routine laboratory conditions. J Clin Virol 2008;.
  
• Allwinn R, Hofknecht N, Doerr HW: Dengue in travellers is still underestimated. Intervirology 2008; 51:96-100.
  
• Wittek M, Sturmer M, Doerr HW, Berger A: Molecular assays for monitoring HIV infection and antiretroviral therapy. Expert Rev Mol Diagn 2007; 7:237-246.
  
• von Hentig N, Babacan E, Staszewski S, Sturmer M, Doerr HW, Lotsch J: Predictive factors for response to a boosted dual HIV-protease inhibitor therapy with saquinavir and lopinavir in extensively pre-treated patients. Antivir Ther 2007; 12:1237-1246.
  
• Sturmer M, Dauer B, Moesch M, Haberl A, Mueller A, Locher L, Knecht G, Hanke N, Doerr HW, Staszewski S: Evolution of resistance mutations during low-level viral replication in HIV-1-infected patients treated with zidovudine/lamivudine/abacavir as a first-line regimen. Antivir Ther 2007; 12:25-30.
  
• Sturmer M, Staszewski S, Doerr HW: Quadruple nucleoside therapy with zidovudine, lamivudine, abacavir and tenofovir in the treatment of HIV. Antivir Ther 2007; 12:695-703.
  
• Schmidt-Chanasit J, Sturmer M, Hahn A, Schad SG, Gross G, Ulrich RG, Heckel G, Doerr HW: Novel approach for genotyping varicella-zoster virus strains from Germany. J Clin Microbiol 2007; 45:3540-5.
  
• Kleinschmidt MC, Michaelis M, Ogbomo H, Doerr HW, Cinatl J, Jr.: Inhibition of apoptosis prevents West Nile virus induced cell death. BMC Microbiol 2007; 7:49.
  
• Cinatl J, Jr., Michaelis M, Doerr HW: The threat of avian influenza a (H5N1): part II: Clues to pathogenicity and pathology. Med Microbiol Immunol 2007; 196:191-201.
  
• Cinatl J, Jr., Michaelis M, Doerr HW: The threat of avian influenza A (H5N1). Part III: Antiviral therapy. Med Microbiol Immunol 2007; 196:203-212.
  
• Cinatl J, Jr., Michaelis M, Doerr HW: The threat of avian influenza A (H5N1). Part I: Epidemiologic concerns and virulence determinants. Med Microbiol Immunol 2007; 196:181-190.
  
• Cinatl J, Jr., Michaelis M, Doerr HW: The threat of avian influenza A (H5N1). Part IV: Development of vaccines. Med Microbiol Immunol 2007; 196:213-225.
  
• Ludwig B, Kraus FB, Allwinn R, Keim S, Doerr HW, Buxbaum S: Loss of varicella zoster virus antibodies despite detectable cell mediated immunity after vaccination. Infection 2006; 34:222-226.
  
• Cinatl J, Jr., Michaelis M, Fleckenstein C, Bauer G, Kabickova H, Scholz M, Rabenau HF, Doerr HW: West Nile virus infection induces interferon signalling in human retinal pigment epithelial cells. Invest Ophthalmol Vis Sci 2006; 47:645-651.
  
• Buxbaum S, Kraus FB, Hahn A, Beck O, Kabartas B, Doerr HW, Ludwig B: Flow cytometric analysis of virus-specific T lymphocytes: practicability of detection of HCMV-specific T lymphocytes in whole blood in patients after stem cell transplantation. J Immunol Methods 2006; 311:164-173.