Clinic of anesthesiology, intensive care and pain control
Study group: Prof. Dr. med. Oliver Habler

Main emphases

Oxygen transport, tissue oxygenation and organ function in different pathophysiologic states of anemic and hypoxic hypoxia (extreme normovolemic hemodilution, hemorrhagic shock, methemoglobinemia).
Preclinical and clinical development of perioperative transfusion alternatives, in particular autologous predonation, acute normovolemic hemodilution, hyperoxic hemodilution, hemoglobin- or perfluorocarbon-based artificial oxygen carriers.
Large and small animal models under general anesthesia and controlled mechanical ventilation

Experimental models

Large animal models under general anesthesia and controlled mechanical ventilationStandardized, computer-controlled induction of a critcally reduced global or local oxygen delivery by:

extreme normovolemic anemia to the individual critical
acellular fluid resuscitation from hemorrhagic shock
critical methemoglobinemia
experimental induction of a critical coronary stenosis (open chest preparation)

Resources and Abilities

Macrohemodynamics: blood volume (ICG-dilution kinetics), blood pressures (arterial, pulmonary, intracardial), cardiac output (thermodilution, ultrasonic Doppler flowprobes), vascular resistances.
Myocardial perfusion and function: coronary blood flow (ultrasonic Doppler flowprobes), systolic and diastolic leftventricular function (conductance technique)· Global oxygen transport: total body oxygen delivery and consumption (metabolic monitor: Deltatrac).
Local oxygen transport: left ventricular myocardial oxygen delivery and consumption.
Tissue oxygenation: local tissue oxygen partial pressure (8-wire platinum surface electrode), metabolic indicators for tissue hypoxia.
Development of medical software (BFA-System, DeltaCrit-System)
Computerized analysis of regional blood flow heterogeneity (fractal dimensioning)

Publications

Meier J, Kemming GI, Kisch-Wedel H, Blum J, Pape A, Habler OP.
Hyperoxic ventilation reduces six-hour mortality after partial fluid resuscitation from hemorrhagic shock.
Shock. 2004 Sep;22(3):240-7.
Habler O, Meier J, Pape A, Zwissler B. Indications for blood transfusion during orthopedic surgery. Orthopaede, in press
Meier J, Kemming G, Kisch-Wedel H, Blum J, Pape A, Habler O. Hyperoxic ventilation reduces six-hour mortality after partial fluid resuscitation from hemorrhagic shock.
Habler O, Schwenzer K, Zimmer K, Prager M, Konig U, Oppenrieder K, Pape A, Steinkraus E, Reither A, Buchrot A, Zwissler B. Effects of standardized acute normovolemic hemodilution on intraoperative allogeneic blood transfusion in patients undergoing major maxillofacial surgery. Int J Oral Maxillofac Surg 2004, 33(5):467-75.
Meier J, Kemming G, Kisch-Wedel H, Wölkhammer S, Habler O. Hyperoxic ventilation reduces 6-hour mortality at the critical hemoglobin concentration. Anesthesiology 2004, 100(1):70-6.
Meier J, Wolkhammer S, Habler O. The DeltaCrit System (DCS): a computer program for standardized bedside detection of critical oxygen delivery using the Deltatrac II metabolic monitor. Comput Biol Med 2003, 33(5):395-405.
Kemming GI, Meisner FG, Kleen M, Meier JM, Tillmanns J, Hutter JW, Wojtczyk CJ, Packert KB, Bottino D, Habler OP. Hyperoxic ventilation at the critical haematocrit. Resuscitation 2003, 56(3):289-97.
Lang P, Thrun B, Hofstetter B, Haberl C, Strehlke P, Hagenmaier C, Schwenzer K, Habler O. Giant hemangioma of the tongue: combined use of perioperative blood conservation procedures. Anaesthesist 2002, 51(6):470-4.
Kemming GI, Meisner FG, Kleen M, Habler OP. Calculation is unsuitable for determination of O2-consumption (VO2) in case of O2-supply-dependency. Eur J Med Res 2002, 7(4):139-48.
Habler O, Kleen M, Kemming G, Zwissler B. Hyperoxia in extreme hemodilution. Eur Surg Res 2002, 34(1-2):181-7.
Pape A, Kemming G, Meisner F, Kleen M, Habler O. Diaspirin cross-linked hemoglobin fails to improve left ventricular diastolic function after fluid resuscitation from hemorrhagic shock. Eur Surg Res 2001; 33(5-6):318-26.
Meisner FG, Kemming GI, Habler OP, Kleen MS, Tillmanns JH, Hutter JW, Bottino DA, Thein E, Meier JM, Wojtczyk CJ, Pape A, Messmer K. Diaspirin crosslinked hemoglobin enables extreme hemodilution beyond the critical hematocrit. Crit Care Med 2001, 29(4):829-38.
Bottino DA, Kleen M, Kemming G, Meisner F, Habler O, Messmer K. Three-dimensional visualization of lung blood flow heterogeneity based on fluorescent microsphere technique and fractal dimension: The Blood Flow Analysis System - BFA System. Methods Programs Biomed 2001, 65(1):79-87.
Habler O, Kleen M, Pape A, Meisner F, Kemming G, Messmer K. Diaspirin-crosslinked hemoglobin reduces mortality of severe hemorrhagic shock in pigs with critical coronary stenosis. Crit Care Med. 2000 Jun;28(6):1889-98.·
Habler OP, Messmer KF. Tissue perfusion and oxygenation with blood substitutes. Adv Drug Deliv Rev 2000, 40(3):171-84.
Hutter J, Habler O, Kleen M, Tiede M, Podtschaske A, Kemming G, Corso C, Batra S, Keipert P, Faithfull S, Messmer K. Effect of acute normovolemic hemodilution on distribution of blood flow and tissue oxygenation in dog skeletal muscle. J Appl Physiol 1999, 86(3):860-6.
Habler O, Messmer K. Hyperoxaemia in extreme haemodilution. Br J Anaesth 1998, Suppl 1:79-82.
Kleen M, Habler O, Hutter J, Podtschaske A, Tiede M, Kemming G, Welte M, Keipert PE, Batra S, Faithfull NS, Corso C, Messmer K. Normovolaemic haemodilution and hyperoxia have no effect on fractal dimension of regional myocardial perfusion in dogs. Acta Physiol Scand 1998, 162(4):439-46.
Habler OP, Kleen MS, Hutter JW, Podtschaske AH, Tiede M, Kemming GI, Welte MV, Corso CO, Batra S, Keipert PE, Faithfull NS, Messmer KF. Hemodilution and intravenous perflubron emulsion as an alternative to blood transfusion: effects on tissue oxygenation during profound hemodilution in anesthetized dogs. Transfusion 1998, 38(2):145-55.
Habler OP, Kleen MS, Hutter JW, Podtschaske AH, Tiede M, Kemming GI, Welte MV, Corso CO, Batra S, Keipert PE, Faithfull NS, Messmer KF. Effects of hyperoxic ventilation on hemodilution-induced changes in anesthetized dogs. Transfusion 1998, 38(2):135-44.