Georg-Speyer-Haus -
Prof. Dr. Bernd Groner

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Expertise

• Regulation of cell proliferation and interference with components of signal transduction
  
• Applied virology and gene therapy
  
  

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Staff

• Prof. Dr. Winfried Wels (Cancer immunotherapy targeting growth factor receptors and other differentially expressed tumor antigens)
  
• Prof. Dr. Dorothee von Laer (Viruses as tools and targets for therapy)
  
• Dr. Manuel Grez (Molecular approaches for the treatment of congenital and acquired diseases of the blood system)
  
• Dr. Ursula Dietrich (New antiviral strategies)
  
• Dr. Martin Zörnig (Regulation and deregulation of apoptosis)
  
• Dr. Jörn Lausen (Transcripiton factor regulation in development and disease)
  
• Dr. Joachim Koch (Ligand recognition and modulation of NK cell receptors)

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Publications

• Groner B, Lucks P, Borghouts-Heinz C: The function of Stat3 in tumor cells and their microenvironment. Seminars in Cell and Developmental Biology 2008; 19:in press.
  
• Groner B, Borghouts C: Getting a grip on signalling pathways: a crucial challenge for basic research in oncology. Geburtsh Frauenheilk 2008; 68:244-250.
  
• Brill B, Groner B, Boecher N, Shemanko C: A sparing procedure to clear the mouse mammary fat pad of epithelial components for transplantation analysis. Lab Anim 2008; 42:104-110.
  
• Borghouts C, Kunz C, Groner B: Peptide aptamer libraries. Comb Chem High Throughput Screen 2008; 11:133-145.
  
• Borghouts C, Kunz C, Delis N, Groner B: Monomeric recombinant peptide aptamers are required for efficient intracellular uptake and target inhibition. Mol Cancer Res 2008; 6:267-281.
  
• Eilton T, Groner B, Barash I: Tumors caused by overexpression and forced activation of Stat5 in mammary epithelial cells of transgenic mice are parity-dependent and developed in aged, postestropausal females. Int J Cancer 2007; 121:1892-1902.
  
• Groner B: Introduction: the rationale for the development of targeted drugs in cancer therapy. Recent Results Cancer Res 2007; 172:1-3.
  
• Desrivieres S, Prinz T, Kuhn K, Schäfer J, Castro-Palomino-Laria N, Neumann T, Schwartz J, Hamon C and Groner B: Comparison of the nuclear proteomes of mammary epithelial cells at different stages of functional differentiation. Proteomics 2007; 7:2019-2037.
  
• Groner B: The rational for the development of targeted drugs in cancer therapy. Recent Results in Cancer Research: Clinical Relevance of the Targeted Interference with Signal Transduction Events (edited by B. Groner), Springer Verlag Heidelberg 2006;: in press.
  
• McGee S, Lanigan F, Gilligan E, Groner B: Mammary gland biology and breast cancer: common molecular mechanisms of mammary gland development and breast cancer progression. EMBO Reports 2006; 7:1084-1088.
  
• Kunz C, Borghouts C, Buerger C, Groner B: Peptide aptamers with binding specifity for the intracellular domain of the ErbB2 receptor interfere with heregulin induced signalling and sensitize ErbB2 expressing breast cancer cells to taxol induced cell death. Mol Cancer Res 2006; 4:983-998.
  
• Jankiewicz M, Groner B, Desrivieres S: mTOR regulates the growth of mammary epithelial cells through the inhibitor of DNA binding Id1 and their functional differentiation through Id2. Mol Endo 2006; 20:2369-2381.
  
• Iavnilovitch E, Eilon T,Groner B, Barash I: Expression of a carboxyl-terminally truncated Stat5, lacking a transactivation domain, in the mammary gland of transgenic mice inhibits cell proliferation during pregnancy, delays onset of milk secretion and enhances apoptosis upon involution. Molecular Reproduction and Development 2006; 73:841-849.
  
• Desrivieres S, Kunz C, Barash I, Vafaizadeh V, Borghouts C, Groner B: The biological functions of the versatile transcription factors Stat3 and Stat5 and new strategies for their targeted inhibition. J Mammary Gland Biology and Neoplasia 2006; 11:75-87.