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Central Laboratory of German
Pharmacists-
Prof. Dr. Schubert-Zsilavecz
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Expertise
- Drug analyses:
- identity and purity testing
as well as content uniformity
- compatability studies of
drugs and excipients
- long-term stability follow-up
and stress testing on drugs
and drug formulation
- according to ICH guidelines
- In vitro release of solid
and semi-solid dosage forms
- Quality control of herbs
and extracts as well as herbal
formulations
- Caco-2 permeability assay
- Pharmacokinetics and metabolism
- development of bioanaytical
methods and their validation
conforming to GMP guidelines
- compilation of concentration-time-profiles
of drug candidates using equipments
of the highest
technical standards e.g. LC/MS/MS
- development of sensitive
and specific analytical methods
for the identification and
quantification
of metabolites
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Resources
and Abilities
- Liquid chromatography with
UV-, DAD- and fluorometric
detection
- Mass spectrometry (LC/MS/MS)
- Gas chromatography with
FID- and ECD-detection
- Atomic absorption spectroscopy
- Infrared spectroscopy (Diamant-ATR-FT-IR)
- UV-Vis-Spectroscopy
- Dissolution (paddle, basket,
franz diffusion cell)
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Publications
- Keller J-H, Müller
W E, Volmer D A, Eckert G
P, Abdel Tawab M, Blume H,
Dingermann T, Schubert-Zsilavecz.
Determination of Hyperforin
in mouse Brain by High Performance
Liquid Chromatography /Tandem
Mass Spectrometry. Anal Chem
2003; 75, 6084 –6088.
- Abdel Tawab M, Bahr U, Karas
M, Wurglics M, Schubert-Zsilavecz
M. Degradation of Ginsenosides
in Humans after Oral Administration.
Drug Metab Dispos 2003; 31,
1065-1071.
- Kaunzinger A, Krumme D,
Potthast H, Petri J, Schmitt
E, Grötsch P. Ciprofloxacin-Präparate
im Vergleich. PZ 2003; 148
(44), 32-36.
- Glaab V, Ihrig M, Potthast
H. Hydrochlorothiazid-Präparate
im Vergleich. PZ 2003; 148
(33), 24-27.
- Glaab V und Ihrig M. Paracetamol
500 mg Tabletten im Vergleich.
DAZ 2003; 148 (33), 47-49.
- Abdel Tawab M, Kaunzinger
A, Bahr U, Karas M, Wurglics
M, Schubert-Zsilavecz M. Development
of high performance liquid
chromatographic method for
the determination of 11-keto-b-boswellic
acid in human plasma. J Chromat
B 2001, 761, 221-227.
- Abdel Tawab M, Bahr U, Danieli
B, Gebhardt S, Karas M, Riva
S, Schubert-Zsilavecz M. Electrospray
mass spectrometry with consecutive
fragmentation steps as a tool
for rapid and sensitive analysis
of ginsenosides and their
galactosy derivatives. Helv
Chim Acta 2000, 83, 739-747.
- Potthast H, Mircioiu I,
Bastian B, Möller H.
Biopharmazeutische Charakterisierung
von Diclofenac-Präparaten.
PZ 2001; 147 (45)
- Ihrig M, Ali S. Qualität
von Drogen der Traditionellen
Chinesischen Medizin. PZ 2001;
147 (6)
- Möller H, Potthast
H. Biopharmazeutische Charakterisierung
von Arzneistoffen und Fertigarzneimittel.
PZ 1999; 145 (20)
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Staff:
- Dr. Mona Tawab (Assistant
of the Scientific Management)
- Dr. Astrid Kaunzinger (Starting-materials,
finished products)
- Dr. Michael Ihrig (Pharmacokinetics,
Biopharmaceutics, pharmaceutical
development)
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ZAFES-Coordinator:
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